Blog Archives


SYSCOL Networking symposium Barcelona November 4th, 2013

Welcome to our networking symposium titled SYSTEMS BIOLOGY APPROACHES TO CANCER MEDICINE, which will be held at the HUB Auditorium, Bellvitge University Hospital, Barcelona on November 4th 2013 NETWORKING SYMPOSIUM POSTER_final


Training Course on Pathways, Networks and Systems, October 15-17, Oeiras, Portugal

This training course provides hands-on experience on the analysis and modeling of biological systems from several angles. First of all,  systems biology and modeling will be introduced from an interaction- and network-based perspective. The audience will be familiarized with publicly available data resources and pathways databases. Next, a soft introduction to mathematical modeling of biological systems will be provided, and different mathematical modeling strategies will be looked at. Then, methods for reconstructing gene regulatory networks from gene expression data will be looked. The participants will also be developing group work towards the validation of such drug targets, with the help of dynamic modeling of the network systems. More information and registration


Systems Biology workshop October 18-19 Oeiras Portugal

The Systems Biology workshop “PathProt-6: Pathways in Proteomics” will be held on October 18th and 19th 2013, at Rua da Quinta Grande, 6, Oeiras, Portugal. PathProt is the international forum for Pathway Analysis in Proteomics. They are an informal discussion group that meets annually to listen to invited and submitted talks, discuss freely and summarize the results. Read more


SYSCOL Meeting Barcelona November 4-5

The annual SYSCOL meeting will be held in Barcelona on November 4-5.


Cell memory mechanism discovered

The cells in our bodies can divide as often as once every 24 hours, creating a new, identical copy. DNA binding proteins called transcription factors are required for maintaining cell identity. They ensure that daughter cells have the same function as their mother cell, so that for example muscle cells can contract or pancreatic cells can produce insulin.  However, each time a cell divides the specific binding pattern of the transcription factors is erased and has to be restored in both mother and daughter cells. Previously it was unknown how this process works, but now scientists at Karolinska Institutet have discovered the importance of particular protein rings encircling the DNA and how these function as the cell’s memory. Press release,  KI Press room Article in Cell  


High Throughput Biology 2013 Karolinska Institutet, Huddinge, June 3-4th

Welcome to the third High Throughput Biology Symposium This two day meeting gathers a distinguished group of European and international research pioneers, covering prominent high throughput research areas in Systems Biology and Functional Genomics. Topics for the scientific sessions are: Single cell genomics and gene expression Genetic interactions RNAi and somatic cell genetics Protein-DNA interactions Cancer The meeting also highlights existing opportunities for academic and industrial researchers to access automated cell-based and biochemical technologies based at the Karolinska High Throughput Center; home to one of the most sophisticated, state-of-the-art, ultra-high performance liquid handling and analysis platforms in Europe. More information can be found at the High Throughput Biology 2013 webpage.


SYSCOL Open Session Oxford March 20

We would like to invite you to listen to presentations of the latest work within the SYSCOL project at Queen’s College Oxford on Wednesday March 20 2013 in the Memorial Room starting at 9.00 am. SYSCOL OPEN SESSION AGENDA


Bert Vogelstein, M.D., Awarded Breakthrough Prize in Life Sciences

SYSCOL member Bert Vogelstein, M.D., co-director of the Ludwig Center at Johns Hopkins, Clayton Professor of Oncology at the Sidney Kimmel Comprehensive Cancer Center, and a Howard Hughes Medical Institute investigator, has been awarded the Breakthrough Prize in Life Sciences. The prize was created by Sergey Brin and Anne Wojcicki, Mark Zuckerburg and Priscilla Chan and Yuri Milner to reward scientists working to cure disease and extend human life. Each of the 11 winners will recieve $3 million. This is the first year the prize has been awarded. Vogelstein graduated from the Johns Hopkins School of Medicine in 1974 and began studying pediatrics at The Johns Hopkins Hospital. Seeing young children suffering from cancer spurred his interest in the disease. He spent two years at the National Cancer Institute before returning to Johns Hopkins in 1978 to direct the cancer … Continue reading


Rare genetic faults identified in families with bowel cance

Rare DNA faults in two genes have been strongly linked to bowel cancer by Oxford University researchers, who sequenced the genomes of people from families with a strong history of developing the disease. http://www.ncbi.nlm.nih.gov/pubmed/23263490    


Learning the alphabet of gene control

Scientists at Karolinska Institutet have made a large step towards the understanding of how human genes are regulated. In a new study, published in the journal Cell, they identified the DNA sequences that bind to over four hundred proteins that control expression of genes. This knowledge is required to understand how differences in genomes of individuals affect their risk to develop disease.       http://www.cell.com/abstract/S0092-8674%2812%2901496-1